Native Undenatured Tertiary Intact Collagen Type II
Nautient-II is the newest undenatured collagen for joint health promotion. Your trusted source of scientifically sound undenatured tertiary intact collagen type II, extracted from European salmon nasal cartilage. Produced from high quality, sustainable and fresh Atlantic salmon off-cuts, our low-impact manufacturing process provides a product with superior nutritional profile and proven health promotional properties. Nautient-II has unique dual health benefits due to the additional presence of proteoglycans providing a chondroprotective and anti-inflammatory effect.
Type II collagen & proteoglycan and its function for joint health
Type II collagen is the major protein in cartilage tissue, providing tensile strength and toughness to the joints. Many joint disorders proceed through inflammatory pathways leading to cartilage degradation. This is majorly caused due to an immune response against endogenous type II collagen which is causing an inflammatory response. Type II collagen, in its tertiary intact and undenatured form, acts as a modulator of this inflammatory immune response at low dosing regimen. Due to the presence of proteoglycans from the salmon nasal cartilage, Nautient-II is uniquely positioned for joint health application. Proteoglycans are functioning in orchestra with undenatured type II collagen and provide additional benefit for joint health having a chondroprotective and anti-inflammatory effect.
Immune modulation mechanism of action
Nautient-II works at very low dose (40 mg/day) through a scientifically studied mechanism called oral tolerance which provides a diminished immune response due to the build-up of receptor tolerance caused by low dose antigen recognition. Oral tolerance is effectuated by the following actions in the body:
- Interaction of the orally ingested type II collagen with Peyer’s patches in the gut, potentiates detection by the immune system.
- Low dose interaction initiates a continuous immune response against endogenous type II collagen thereby lowering the immunological action.
- Providing immunological tolerance, the type II collagen leads to the reduction of collagen degradation in the joints, supporting overall joint health and anti-inflammation.
- Proteoglycans provide additional chondroprotective and anti-inflammatory action further supporting the action of type II collagen.
Nautient-ll
- New generation undenatured type II collagen employing a combination of scientifically backed functioning of undenatured type II collagen and proteoglycan
- Low dosing allowing the build-up of oral tolerance and reduction of inflammatory pathways
- Science backed by demonstration in a plethora of scientific studies¹ ̛¹⁷: Positive effects on joint structure, improving knee discomfort and function, reducing inflammation
- European product, manufactured in The Netherlands and fully originated from Norwegian salmon
- Halal certified, non GMO
- 100% salmon, no additives